Affinity purification combined with mass spectrometry (AP-MS) is used to catalog protein-protein interactions (PPIs) for 40 proteins significantly altered in breast cancer, including multidimensional measurements across mutant and normal protein isoforms and across cancerous and noncancerous cellular contexts.
MuSIC is a hierarchical map of the eukaryotic cell architecture created from integrating immunofluorescence images in the Human Protein Atlas with affinity purification experiments from the BioPlex resource.
DCell is a deep neural network model of budding yeast, a basic eukaryotic cell. The model structure corresponds exactly to a hierarchy of 2,526 cellular subsystems. Given this neural network structure, DCell has been trained to translate genotype to phenotype.