The Cancer Cell Map Initiative (CCMI, UC San Diego & UCSF) was excited to host the 2022 CSBC West Coast Symposium. This in-person symposium featured short talks from mostly trainees (graduate students, postdoctoral fellows and staff scientists) from each of the West Coast Centers and Projects in the Cancer Systems Biology Consortium (CSBC).

In addition to the scientific presentations below, there was a welcome reception at the hotel on Wednesday night (March 9) and a harbor cruise with dinner on Thursday (March 10). The Symposium concluded with lunch on Friday (March 11).

Thursday, March 10, 2022

9:00 - 10:15 am, Session 1 chaired by Michelle Digman (UC Irvine)

• Zinab Doha (OHSU), MYC-driven therapeutic resistance in triple-negative breast cancer
• Marcus Kelly (UC San Diego), Interpretation of cancer mutations using a multiscale map of protein systems
• Michelle Digman (UC Irvine), FLIM and mitometer enable metabolic profiling and tracking phenotypic changes in mitochondria in cancer cells
• Eleni Farmaki (City of Hope), Acquired sensitivity to TIC10/ONC201 in ER breast cancer progressing on the mTOR inhibitor everolimus
• Kevin Brennan (Stanford University), Survival and metastasis are associated with distinct cellular processes in head and neck cancer

10:45 am - 12:00 pm, Session 2 chaired by Jim Costello (Univ of Colorado)

• Adam Taylor (Sage Bionetworks), Enabling FAIR imaging in HTAN: schema, workflows and visualization
• Gabriel Yette (University of Colorado), Characterizing novel aggressive prostate cancer subtypes associated with loss of chromosomes 8p and 16q
• Patrick O'Leary (UCSF), Resistance to ATR inhibitors mediated by loss of the nonsense-mediated decay factor UPF2
• Jonathan Rodriguez (UC Irvine), Predictive nonlinear modeling of malignant myelopoiesis and TKI therapy
• Pamela Winfrey (Arizona State University), In search of chemozoa

2:00 pm - 3:15 pm, Session 3 chaired by Kristin Swanson (Mayo Clinic)

• Yue Qin (UC San Diego), A multi-scale map of cell structure fusing protein images and interactions
• David Frankhouser (City of Hope), Patterns of gene and microRNA expression identify dynamics that predict AML development
• William Yashar (OHSU), Profiling transcription factor activity through evidence-based regulatory interactions
• Furkan Kurtoglu (Indiana University), Multiscale modeling of colorectal cancer using agent-based modeling and flux balance analysis
• Song Feng (Pacific Northwest National Laboratory), Integrating structural bioinformatics with phosphoproteome analysis and modeling

3:45 pm - 5:00 pm, Session 4 chaired by Peter Lee (City of Hope)

• Hayarpi Torosyan (UCSF), Decoding the molecular function of the HER3 pseudokinase as a dynamic PI3K scaffold
• Michael Kochen (Pacific Northwest National Laboratory), Modeling the EGF pathway, challenges and pitfalls
• Peter Lee (City of Hope), Immune signaling networks in health and cancer
• Brian Orcutt-Jahns (UCLA), Systems engineering of IL-2 identifies multivalency as an unexplored axis of cell-specific therapies
• Ian McLean (OHSU), Oncostatin M induces HIF1A-dependent collective cell migration in mammary epithelial cells

Friday, March 11, 2022

9:00 am - 10:15 am, Session 5 chaired by Laura Heiser (OHSU)

• Bogdan Luca (Stanford University), Atlases of clinically-distinct cell states and cellular ecosystems in solid cancers and diffuse large B cell lymphoma
• Patrick Cosgrove (City of Hope), Cell composition and communication in tumor resistance and evolution 
• Lujia Wang (Mayo Clinic), Quantifying modeling of intra-tumoral heterogeneity of multiple gene drivers of GBM using MRI and machine learning
• Almudena Espin Perez (Stanford University), Genomic and proteomic changes from dissociation techniques
• Michael Reich (UC San Diego), The GenePattern Notebook environment for cancer research

10:45 am - 12:00 pm, Session 6 chaired by Jeffrey Chang (Univ of Texas)

• Calum Gabbutt (Barts Cancer Institute), Cell lineage tracing with molecular clocks based on fluctuating DNA methylation
• Jeffrey Chang (University of Texas), Genomic and transcriptomic dissection of multi-site breast cancer metastasis tumors from a rapid autopsy program
• Jenny Eng (OHSU), Multiplex imaging reveals prognostic spatial signatures in the breast tumor microenvironment
• Gina Bouchard (Stanford University), Role of spatially distinct tumor fibroblast in erlotinib resistance 
• Zachary Compton (Arizona State University), A life history model of reproductive cancers across mammals

Pictures of Scientists Having Fun